Drug intelligence / Profile preview

bupivacaine + lidocaine (University Health Network)

Development stage
Unknown
Lead developer
Pine Pharmaceuticals
Modality
Small Molecules
Administration
Perineural
01

Overview

This intervention refers to a regional anesthetic technique involving a combination of the local anesthetics **bupivacaine** (0.5%) and **lidocaine** (2%) administered under ultrasound guidance. Developed and studied by the **University Health Network, Toronto**, it is specifically evaluated for managing **post-operative pain** and providing surgical anesthesia for hand and wrist procedures. By targeting nerves below the elbow (radial, ulnar, and median nerves), the block aims to provide effective analgesia while preserving proximal arm mobility compared to traditional brachial plexus blocks. The combination leverages the rapid onset of lidocaine and the long-lasting effects of bupivacaine to optimize patient recovery and satisfaction in the immediate post-operative period.

Other names
Forearm Nerve BlockForearm BlockUHN Forearm Nerve Block
02

Targets

Kir (Inward-rectifier potassium channels)NaV (Voltage-gated sodium channels)CaV (Voltage-gated calcium channel protein complex)NMDAR (Glutamate receptor ionotropic, NMDA)

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