Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
bupivacaine + lidocaine + epinephrine + sodium bicarbonate
- Development stage
- Unknown
- Lead developer
- Hospital Italiano de Buenos Aires
- Modality
- Small Molecules
- Administration
- Subcutaneous, Perineural
01
Overview
bupivacaine + lidocaine + epinephrine + sodium bicarbonate is a multi-component local anesthetic solution being evaluated by the Hospital Italiano de Buenos Aires for the management of postoperative pain following carpal tunnel release surgery. This combination therapy utilizes bupivacaine and lidocaine, both amide-type local anesthetics that block voltage-gated sodium channels to prevent the conduction of nerve impulses. Lidocaine provides a rapid onset of action, while bupivacaine offers a longer duration of analgesia. Epinephrine is included as a vasoconstrictor to prolong the local effect and reduce systemic toxicity by slowing absorption. Sodium bicarbonate is added as a buffering agent to adjust the pH of the solution, which can decrease the pain of injection and potentially speed the onset of the anesthetic block.
- Other names
- bupivacaine and lidocaine combinationbupivacaine/lidocaine/epinephrine/sodium bicarbonate
02
Targets
ADRA2A (α2A)ADRB1 (β1)β-AR (Beta-adrenergic receptor family)NaV (Voltage-gated sodium channels)ADRA1A (α1A)ADRB2 (β2)
Beyond the preview
Go deeper on bupivacaine + lidocaine + epinephrine + sodium bicarbonate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on bupivacaine + lidocaine + epinephrine + sodium bicarbonate.