bupivacaine + morphine (Assiut University)

bupivacaine + morphine is a combination analgesic regimen administered via paravertebral block (PVB) for the management of acute postoperative pain. This specific formulation, investigated by Assiut University, utilizes morphine as an adjuvant to the local anesthetic bupivacaine. Morphine acts as a potent mu-opioid receptor agonist, providing analgesia through the modulation of pain perception in the central nervous system. Bupivacaine is a long-acting local anesthetic that functions by blocking voltage-gated sodium channels, thereby inhibiting nerve impulse conduction in the paravertebral space. The combination is primarily studied for its efficacy in reducing pain scores and opioid consumption following major surgical procedures, such as breast and renal surgeries.

Other names

PVB morphineparavertebral morphinePVB morphine-Assiut University-acute postoperative pain