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bupivacaine + ropivacaine + epinephrine + dexamethasone
- Development stage
- Preclinical
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Epidural, Perineural, Infiltration, Intrathecal, Intraarticular
01
Overview
A combination of two amide-type local anesthetics (bupivacaine and ropivacaine), a vasoconstrictor (epinephrine), and a corticosteroid (dexamethasone). This combination likely provides prolonged anesthesia and analgesia with reduced systemic absorption due to the vasoconstrictor effect of epinephrine, while dexamethasone may extend the duration of the nerve block and provide anti-inflammatory effects.
02
Targets
NaV (Voltage-gated sodium channels)GR (Glucocorticoid receptor)AR (Adrenergic receptors)
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