Drug intelligence / Profile preview

bupivacaine + tramadol (Dışkapı Yıldırım Beyazıt Training and Research Hospital)

Development stage
Unknown
Lead developer
Dışkapı Yıldırım Beyazıt Training and Research Hospital
Modality
Small Molecules
Administration
Intravenous, Regional
01

Overview

The drug name refers to a specific multimodal analgesic intervention protocol evaluated by Diskapi Teaching and Research Hospital for the management of acute postoperative pain in patients undergoing lumbar disc surgery. This intervention consists of an ultrasound-guided erector spina plane (ESP) block using the local anesthetic **bupivacaine**, combined with systemic analgesia provided via intravenous patient-controlled analgesia (IV-PCA) using **tramadol**. The ESP block is a regional anesthesia technique where local anesthetic is injected into the fascial plane deep to the erector spinae muscle, targeting the dorsal rami of spinal nerves to provide regional analgesia. This combination therapy aims to reduce postoperative pain scores, decrease total opioid consumption, and prolong the time to the first analgesic requirement compared to standard IV-PCA alone.

Other names
Erector spina plane block-Diskapi Teaching and Research Hospital-postoperative painErector spina plane blockESP blockESPbupivacaine + tramadol (ESP block)
02

Targets

NET (Norepinephrine Transporter)MOR (Mu opioid receptor)SERT (Sodium-dependent serotonin transporter)NaV (Voltage-gated sodium channels)

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