Drug intelligence / Profile preview

bupivacaine hydrochloride + povidone-iodine + lidocaine hydrochloride + triamcinolone

Development stage
Preclinical
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Topical, Parenteral, Percutaneous
01

Overview

**Bupivacaine hydrochloride + povidone-iodine + lidocaine hydrochloride + triamcinolone** is a compounded multi-component small-molecule drug kit used for local or regional anesthesia and analgesia. The combination includes two amide local anesthetics, bupivacaine hydrochloride and lidocaine hydrochloride, which reduce pain transmission primarily by reversibly blocking voltage-gated sodium channels in peripheral nerves; triamcinolone provides local corticosteroid anti-inflammatory activity via glucocorticoid receptor agonism and downstream suppression of inflammatory gene expression; and povidone-iodine serves as a topical antiseptic through broad microbicidal iodine release. The product has been described under kit names such as MLK F4 KIT, BLT-25 KIT, and P-CARE K40MX/K80MX, including by Asclemed USA, for procedural pain control and related local anesthetic use. It is best characterized as an unapproved compounded combination product rather than an FDA-approved single branded drug.

Brand names
MLK F4 KITBLT-25 KITBLT25 KITBLT 25 KITP-CARE K40MXP-CARE K80MX
Other names
bupivacaine hydrochloride + povidone-iodine + lidocaine hydrochloride + triamcinolonebupivacaine hydrochloride + lidocaine hydrochloride + povidone-iodine + triamcinolone
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)PTGER1 (Prostaglandin E Receptor 1)

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