bupropion + fluoxetine

Bupropion + fluoxetine is a combination of two antidepressants with different mechanisms of action. Bupropion (Wellbutrin) is a norepinephrine-dopamine reuptake inhibitor (NDRI), while fluoxetine (Prozac) is a selective serotonin reuptake inhibitor (SSRI). This dual-mechanism approach targets different neurotransmitter systems that regulate mood. The combination is sometimes used for treatment-resistant depression or when a patient has had an incomplete response to SSRI therapy alone, potentially providing enhanced antidepressant efficacy and mitigating SSRI-associated sexual dysfunction. However, it requires careful medical supervision due to potential interactions and carries significant risks including increased seizure potential (bupropion lowers the seizure threshold) and possible serotonin syndrome.

Other names

fluoxetine + amfebutamone