buspirone + citalopram

Buspirone + citalopram is a combination of two oral small molecule drugs used together, primarily in the management of major depressive disorder and treatment-refractory depression. Buspirone is an anxiolytic agent that acts as a serotonin 5-HT1A receptor partial agonist, while citalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonergic activity by inhibiting the reuptake of serotonin in the central nervous system. The combination has been studied for augmentation in patients who do not respond adequately to SSRI monotherapy. However, concomitant use increases the risk of serotonin syndrome and requires close monitoring due to potential drug interactions[1][2][3][5].