butyrate + polyphenol

Butyrate + polyphenol is an investigational oral dietary supplement formulation that combines **butyrate**, a short-chain fatty acid (typically delivered as sodium butyrate or butyrylated starch), with one or more **polyphenols** (a class of plant-derived antioxidant compounds such as resveratrol, curcumin, quercetin, chlorogenic acid, etc.). This combination is designed to synergistically support gut health by: - Improving intestinal barrier function and reducing gut permeability - Modulating the gut microbiota, increasing beneficial bacteria (e.g., *Lactobacillus*, *Bifidobacterium*, *Akkermansia*) and butyrate-producing microbes - Reducing inflammation and the severity of colitis, and exerting anti-cancer activities (notably in colitis-associated colorectal cancer) by altering microbe-host interactions and producing beneficial microbial metabolites - Polyphenols exert additional effects by selectively targeting pathogenic or proinflammatory bacteria, influencing iron availability, disrupting quorum sensing, DNA/RNA synthesis, membrane function, and biofilm formation This combination is being investigated primarily for **gut health**, especially conditions such as colitis and colorectal cancer, and may also benefit other gut and metabolic disorders[1][2][3].