Drug intelligence / Profile preview

cabotegravir + rilpivirine

Development stage
Approved
Lead developer
ViiV Healthcare
Modality
Small Molecules
Administration
Intramuscular
01

Overview

**Cabotegravir + rilpivirine** is a complete, long-acting, two-drug antiretroviral regimen for maintenance treatment of **HIV-1 infection** in people with virologic suppression. Marketed in the United States as **Cabenuva**, it is supplied as co-packaged extended-release intramuscular suspensions: cabotegravir, an HIV-1 integrase strand-transfer inhibitor, and rilpivirine, a non-nucleoside reverse transcriptase inhibitor. The regimen is administered as separate gluteal intramuscular injections on a monthly or every-two-month schedule. Cabotegravir was developed by ViiV Healthcare and rilpivirine by Janssen; the long-acting regimen was co-developed through their collaboration.

Brand names
Cabenuva
Other names
CAB+RPVCAB+RPV LACAB/RPVcabotegravir + rilpivirinecabotegravir/rilpivirineLA-CAB/RPVlong-acting cabotegravir + rilpivirine
02

Targets

Human immunodeficiency virus type 1 reverse transcriptaseIntegrase allosteric pocket (HIV)

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