Drug intelligence / Profile preview

cadonilimab + pulocimab + paclitaxel

Development stage
Unknown
Lead developer
Kangfang Sainuo Pharmaceutical
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

cadonilimab + pulocimab + paclitaxel is a combination regimen used in oncology clinical research. **Cadonilimab** is a bispecific monoclonal antibody targeting both PD-1 and CTLA-4, engineered as an immunotherapy to enhance anti-tumor immune responses. **Pulocimab** is a monoclonal antibody that targets LAG-3, another immune checkpoint, also designed for cancer immunotherapy. **Paclitaxel** is a chemotherapeutic agent that stabilizes microtubules, disrupting mitosis and causing cell death in rapidly dividing tumor cells[1][2][3]. This combination regimen is under development for solid tumor malignancies, aiming to synergistically block multiple immune checkpoints while directly targeting tumor cells with cytotoxic chemotherapy.

Other names
taxol
02

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)PDCD1 (Programmed cell death protein 1 receptor)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)TUBB (Tubulin (alpha and beta subunits))

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