Drug intelligence / Profile preview

caffeine + losartan + midazolam + omeprazole

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular, Intranasal
01

Overview

This is a combination of four active pharmaceutical ingredients: - **Caffeine** is a central nervous system stimulant commonly used to increase alertness and reduce fatigue. It acts primarily as an adenosine receptor antagonist. - **Losartan** is an angiotensin II receptor blocker (ARB) used mainly for the treatment of hypertension and to protect the kidneys from damage due to diabetes. It works by blocking the action of angiotensin II, resulting in vasodilation. - **Midazolam** is a short-acting benzodiazepine with anxiolytic, amnestic, hypnotic, anticonvulsant, and muscle relaxant properties. It acts as a positive allosteric modulator at GABA-A receptors. - **Omeprazole** is a proton pump inhibitor (PPI) that reduces gastric acid secretion by irreversibly inhibiting the H^+/K^+-ATPase enzyme system in gastric parietal cells[2][4][5][6][8]. There are no known approved pharmaceutical products or brand names containing this exact combination; it appears to be an investigational or research-use-only mixture rather than a marketed drug product.

02

Targets

ADORA2A (Adenosine A₂A Receptor)ADORA3 (Adenosine A3 receptor)BZD site (GABA-A receptor benzodiazepine site)ADORA2B (Adenosine A2B receptor)AGTR1 (Angiotensin II Type-1 receptor)ADORA1 (Adenosine receptor A1 subtype)ATP4A (Potassium–transporting ATPase alpha chain 1)

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