caffeine + water (Southern Illinois University Carbondale)

C3-Southern Illinois University Carbondale refers to a specific experimental intervention arm (Condition 3) in a clinical study titled "Effects of the Interaction of Caffeine and Hydration on Voice Performance." This intervention involves the oral administration of a 200 mg caffeine tablet in combination with 1 liter of water. Developed by researchers at Southern Illinois University Carbondale, the protocol is designed to evaluate whether high-volume systemic hydration can mitigate the potential degradation of vocal performance caused by caffeine ingestion. Caffeine primarily acts as a non-selective antagonist of adenosine receptors (A1 and A2A), which can lead to increased alertness but also potential dehydration of the vocal fold mucosa; the water component is intended to maintain hydration.

Other names

200mg caffeine and 1 Liter water