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calcipotriene + clobetasol propionate
- Development stage
- Phase 1
- Lead developer
- Sincerus
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Calcipotriene + clobetasol propionate is a topical combination drug used primarily for the treatment of plaque psoriasis. Calcipotriene is a synthetic vitamin D3 analog that works by regulating the growth and differentiation of skin cells, thereby reducing the excessive proliferation seen in psoriatic lesions. Clobetasol propionate is a super-potent corticosteroid that acts by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals, decreasing vasodilation and capillary permeability, and suppressing leukocyte migration to sites of inflammation. The combination leverages both anti-proliferative (calcipotriene) and anti-inflammatory (clobetasol) mechanisms to improve symptoms associated with psoriasis[1][2][3][5].
- Brand names
- EnstilarTaclonexWynzoraDovobet
- Other names
- calcipotriene + clobetasol propionate
02
Targets
GR (Glucocorticoid receptor)VDR (Vitamin D receptor)
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