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Drug intelligence / Profile preview
calcipotriol + betamethasone dipropionate (LEO Pharma)
- Development stage
- Phase 4
- Lead developer
- LEO Pharma
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Daivobet/Dovobet Gel is a topical fixed-dose combination therapy developed by LEO Pharma for the treatment of plaque psoriasis (psoriasis vulgaris). It combines calcipotriol, a vitamin D3 analogue, and betamethasone dipropionate, a potent corticosteroid. Calcipotriol acts by binding to the vitamin D receptor (VDR) to inhibit keratinocyte proliferation and promote normal differentiation, addressing the underlying cellular dysfunction in psoriasis. Betamethasone dipropionate acts on the glucocorticoid receptor to provide anti-inflammatory, antipruritic, and immunosuppressive effects. The gel formulation was designed for once-daily application and received its first major approvals in 2008. It is marketed as Taclonex in the United States and has been evaluated in large-scale Phase 4 studies like PSO-TOP to optimize outpatient care.
- Brand names
- DaivobetTaclonex
- Other names
- calcipotriene + betamethasone dipropionatecalcipotriol/betamethasone dipropionate gel
02
Targets
GR (Glucocorticoid receptor)VDR (Vitamin D receptor)
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