calcipotriol + fluticasone propionate

Calcipotriol + fluticasone propionate is a fixed-dose combination topical treatment being investigated for the treatment of plaque psoriasis, particularly in pediatric populations. Calcipotriol is a synthetic vitamin D3 analog that regulates cell proliferation and differentiation by binding to the vitamin D receptor (VDR), while fluticasone propionate is a potent corticosteroid that exerts anti-inflammatory and immunosuppressive effects through the glucocorticoid receptor. The combination aims to provide synergistic therapeutic benefits by simultaneously targeting keratinocyte hyperproliferation and immune-mediated inflammation, which are central to psoriasis pathogenesis. This specific formulation is notably being developed and studied by Beijing Children's Hospital and Capital Medical University for use in children with plaque psoriasis.

Other names

calcipotriol/fluticasone propionate ointmentcalcipotriol and fluticasone propionate ointment