calcipotriol + halometasone

Calcipotriol + halometasone is a fixed-dose topical combination of two active ingredients used primarily in the treatment of plaque psoriasis and other inflammatory skin conditions. Calcipotriol is a synthetic vitamin D3 analog that modulates keratinocyte proliferation and differentiation by binding to the vitamin D receptor, thereby reducing excessive skin cell growth characteristic of psoriasis. Halometasone is a potent synthetic corticosteroid that acts as an anti-inflammatory, immunosuppressive, and antipruritic agent by binding to the glucocorticoid receptor, inhibiting pro-inflammatory cytokine production and suppressing immune responses in the skin. The combination leverages both agents' mechanisms for improved efficacy over monotherapy with either component alone.

Brand names

None known (no widely recognized brand name for this specific combination; see comments)