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Calcium + cholecalciferol
- Development stage
- Unknown
- Lead developer
- Abiogen
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Calcium + cholecalciferol is a fixed-dose combination of a calcium salt (typically as carbonate or citrate) and vitamin D3 (cholecalciferol). It is used to prevent and treat deficiencies of both calcium and vitamin D, particularly in the elderly or in individuals at risk for osteoporosis. The combination works by providing supplemental calcium for bone mineralization and cholecalciferol to enhance intestinal absorption of dietary calcium. Cholecalciferol itself is converted in the body to its active form (1,25-dihydroxycholecalciferol), which binds to the vitamin D receptor—a nuclear receptor that regulates gene expression involved in bone metabolism and immune function. This combination is widely available over-the-counter as well as by prescription[5][1][8].
- Brand names
- Calcitrate with DCitracal + D
- Other names
- calcium/cholecalciferolcalcium/vitamin Dcalcium and vitamin D3
02
Targets
CaSR (Extracellular calcium-sensing receptor)TRPV6 (Transient receptor potential cation channel subfamily V member 6)VDR (Vitamin D receptor)
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