calcium carbonate + colecalciferol

Calcium carbonate + colecalciferol is a combination of a calcium supplement and Vitamin D3 (cholecalciferol). In the clinical management of endometriosis, this combination is primarily utilized as an 'add-back therapy' for patients undergoing treatment with gonadotropin-releasing hormone (GnRH) agonists, such as leuprorelin. GnRH agonists induce a hypoestrogenic state to alleviate endometriosis symptoms, which can lead to a significant reduction in bone mineral density. The administration of calcium carbonate provides elemental calcium for bone mineralization, while colecalciferol acts as a Vitamin D receptor agonist to enhance intestinal calcium absorption and maintain calcium homeostasis. This specific therapeutic regimen was evaluated by the University of Cagliari in a Phase 4 clinical trial (NCT02420054) to assess its impact on the quality of life and psychological health of women experiencing induced amenorrhea.

Brand names

theiCal-D3theiCal-D-3theiCal-D 3

Other names

calcium carbonate/colecalciferolcalcium and vitamin D3calcium carbonate + cholecalciferol