calcium carbonate + vitamin D3 + alendronate sodium

This is a fixed-dose combination therapy containing three active ingredients: - **Alendronate sodium** is a bisphosphonate that inhibits osteoclast-mediated bone resorption, thereby reducing bone turnover and increasing bone mineral density. It is primarily used to treat and prevent osteoporosis by slowing the breakdown of bone and allowing for increased bone formation. - **Vitamin D3 (cholecalciferol)** facilitates intestinal absorption of calcium and phosphorus, which are essential for maintaining healthy bones. Adequate vitamin D levels are necessary for effective calcium absorption. - **Calcium carbonate** provides supplemental elemental calcium, an essential mineral required to maintain the structural integrity of bones. The combination is indicated for the treatment of osteoporosis in postmenopausal women and men at risk of or diagnosed with osteoporosis, providing both antiresorptive therapy (alendronate) and supplementation with vitamin D3 and calcium to optimize bone health[4][1][2]. The product aims to address multiple aspects of osteoporosis management by combining agents that work synergistically on different pathways involved in bone metabolism.

Brand names

ALENDRONATE PLUS D3 AND CALCIUM SANDOZ