Drug intelligence / Profile preview

calcium chloride + magnesium chloride + sodium lactate + sodium chloride + dextrose

Development stage
Approved
Lead developer
Takeda
Modality
Small Molecules
Administration
Intraperitoneal
01

Overview

**Calcium chloride + magnesium chloride + sodium lactate + sodium chloride + dextrose** is a multi-electrolyte crystalloid peritoneal dialysis solution developed by Baxter Healthcare and manufactured by Baxter Manufacturing Thailand, and marketed in the United States by Vantive US Healthcare under the Dianeal Low Calcium with Dextrose and Dianeal PD-2 with Dextrose brands. It is administered **intraperitoneally** for peritoneal dialysis, primarily in patients with end-stage renal disease or chronic kidney failure undergoing continuous ambulatory peritoneal dialysis. Its therapeutic effect is based on **dextrose-driven osmotic ultrafiltration** across the peritoneal membrane, which promotes removal of excess water and uremic solutes, while **sodium chloride, sodium lactate, calcium chloride, and magnesium chloride** provide an electrolyte-buffered dialysate that helps maintain physiologic electrolyte and acid-base balance. Pharmacologically, it is best characterized as a **peritoneal dialysis solution and electrolyte/carbohydrate replacement formulation** rather than a receptor-targeted drug.

Brand names
Dianeal Low Calcium with DextroseDianeal PD-2 with Dextrose
Other names
calcium chloride + magnesium chloride + sodium lactate + sodium chloride + dextrosemulti-electrolyte peritoneal dialysis solutionperitoneal dialysis solution

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