Drug intelligence / Profile preview

calcium hydroxide + diclofenac sodium

Development stage
Unknown
Lead developer
Mustafa Kemal University
Modality
Small Molecules
Administration
Topical
01

Overview

This is an investigational combination of intracanal medicaments consisting of calcium hydroxide and diclofenac sodium, developed by researchers at Hatay Mustafa Kemal University. It is designed for use during endodontic treatment to manage post-operative pain in patients with symptomatic apical periodontitis. Calcium hydroxide provides antimicrobial properties and a high pH environment, while diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), acts locally to reduce inflammation and pain by inhibiting cyclooxygenase enzymes. The combination is applied as a paste directly into the root canal system following cleaning and shaping procedures.

Other names
CH + DCScalcium hydroxide and diclofenac sodium combination
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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