Drug intelligence / Profile preview

calcium sodium phosphosilicate + sodium fluoride

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Topical
01

Overview

A combination dental therapeutic product containing **calcium sodium phosphosilicate** (CSPS, marketed as NovaMin) and **sodium fluoride** used primarily in oral care formulations, notably toothpastes and prophylaxis pastes, for the reduction of dental hypersensitivity, remineralization of tooth structure, and cavity prevention. CSPS acts by releasing calcium and phosphate ions in response to moisture which precipitate to form a hydroxycarbonate apatite-like layer on exposed dentin tubules, resulting in physical occlusion and reduced hypersensitivity[2][3]. Sodium fluoride delivers fluoride ions that promote remineralization and inhibit demineralization, increasing acid resistance and providing cavity protection[1][3]. The combination offers both immediate sensitivity relief and long-term enamel protection when used regularly. Main indications are **dentine hypersensitivity** and **dental caries prevention**[2][3].

Brand names
Sensodyne Repair and Protect
Other names
calcium sodium phosphosilicate + sodium fluorideCSPS + NaF

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