calendula + Aquaphor + silver sulfadiazine + topical corticosteroids

This is not a single drug product but a standard of care treatment regimen used as the control arm in a clinical trial for the prevention and treatment of radiation dermatitis. The regimen is a combination of several topical agents. It consists of calendula and/or Aquaphor (a petrolatum-based ointment) applied two to six times daily, supplemented with a twice-daily application of either a hydrogel, silver sulfadiazine (an antimicrobial cream), or a topical corticosteroid (an anti-inflammatory agent). This multi-faceted approach aims to protect the skin, prevent infection, and reduce inflammation. The treatment is typically initiated at the start of radiation therapy and continued until the skin reaction subsides.