Drug intelligence / Profile preview

Caltrate + Vitamin D

Development stage
Phase 4
Lead developer
Pfizer
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

Caltrate + Vitamin D is a combination dietary supplement and pharmaceutical product containing calcium carbonate and cholecalciferol (vitamin D3). It is primarily indicated for the prevention and treatment of calcium and vitamin D deficiencies, which are critical for maintaining bone mineral density and preventing skeletal disorders like osteoporosis and osteomalacia. Calcium carbonate provides elemental calcium, a fundamental structural component of the bone matrix. Vitamin D3 acts as a pro-hormone that is metabolically converted to its active form, calcitriol. Calcitriol then binds to the vitamin D receptor (VDR) in the intestinal mucosa, stimulating the expression of calcium transport proteins (such as calbindin) to facilitate the active absorption of dietary and supplemental calcium into the bloodstream. This dual action ensures that sufficient calcium is available and effectively absorbed to support bone health and neuromuscular function.

Brand names
Caltrate 600+DCaltrate 600+D3Caltrate 600+D3 Plus Minerals
Other names
calcium carbonate + cholecalciferolcalcium + vitamin D3calcium + vitamin D
02

Targets

VDR (Vitamin D receptor)

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