Drug intelligence / Profile preview

camphor + menthol

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

Camphor + menthol is a **combination topical medication** used for the temporary relief of minor muscle or joint pain, pruritus (itchiness), and irritation resulting from burns, insect bites, minor cuts, scrapes, rashes (including poison ivy/oak/sumac), as well as cold symptoms when used as a chest rub[1][2][3][6]. Camphor acts as a topical analgesic by producing initial cooling followed by warming sensations, reducing nerve sensitivity to pain and itching[1][6]. Menthol functions similarly, primarily by activating TRP channels, provoking a cooling effect and further analgesia; both ingredients also exhibit potential antimicrobial properties[3][6]. Used primarily in lotion, cream, gel, and ointment forms, this combination is available over the counter.

Brand names
Alevex Pain RelievingAlevex Pain Relieving Roll-OnAnti-Itch Steroid FreeArctic ReliefAvedana Pain Relieving Roll On
Other names
camphor/menthol lotioncamphor and menthol topical
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPV3 (Transient receptor potential vanilloid subtype 3)

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