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camrelizumab + gemcitabine
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination treatment regimen consisting of camrelizumab and gemcitabine-based chemotherapy. Camrelizumab is a humanized monoclonal antibody that targets the programmed cell death protein 1 (PD-1) receptor, acting as an immune checkpoint inhibitor to restore and enhance T-cell mediated anti-tumor activity. Gemcitabine is a pyrimidine nucleoside analog that functions as a cytotoxic chemotherapy agent by inhibiting DNA synthesis. This specific regimen is being evaluated by the Eye & ENT Hospital of Fudan University as a neoadjuvant and adjuvant therapy in conjunction with endoscopic surgery for patients with recurrent nasopharyngeal carcinoma. The protocol typically involves neoadjuvant cycles of the combination followed by surgical intervention and subsequent maintenance therapy with camrelizumab.
- Other names
- CamrelizumabGemcitabine
02
Targets
DNA polymerase familyPDCD1 (Programmed cell death protein 1 receptor)RNR (Ribonucleotide reductase)DNA
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