Drug intelligence / Profile preview

candesartan + hydrochlorothiazide + amlodipine + atorvastatin

Development stage
Unknown
Lead developer
Midas Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

This combination drug is a potential treatment approach for dual cardiovascular risk prevention, simultaneously targeting both hypertension and dyslipidemia. It combines four distinct medications: * **Candesartan**: An angiotensin receptor blocker (ARB) used to lower blood pressure. * **Hydrochlorothiazide**: A thiazide diuretic that reduces blood volume and pressure. * **Amlodipine**: A calcium channel blocker that relaxes blood vessels to ease blood flow. * **Atorvastatin**: An HMG-CoA reductase inhibitor (statin) used to reduce cholesterol levels. This combination aims to provide comprehensive cardiovascular protection by addressing high blood pressure through multiple mechanisms and managing high cholesterol. While specific fixed-dose formulations of all four drugs together may not be widely available, studies on combinations of some of these drugs (like candesartan, amlodipine, and atorvastatin) suggest favorable pharmacokinetic profiles supporting the feasibility of such combinations.

02

Targets

AGTR1 (Angiotensin II Type-1 receptor)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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