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candesartan cilexetil + amlodipine besylate
- Development stage
- Unknown
- Lead developer
- HanAll BioPharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Candesartan cilexetil + amlodipine besylate is a fixed-dose combination (FDC) therapy developed by HK inno.N Corporation (formerly CJ HealthCare) for the management of essential hypertension. The combination leverages two distinct mechanisms of action: candesartan cilexetil, an angiotensin II receptor blocker (ARB), selectively antagonizes the AT1 receptor to inhibit the vasoconstrictive and aldosterone-secreting effects of angiotensin II; amlodipine besylate, a dihydropyridine calcium channel blocker (CCB), inhibits the influx of calcium ions into vascular smooth muscle, leading to direct vasodilation. Together, these agents provide a synergistic reduction in peripheral vascular resistance and blood pressure. This FDC is particularly utilized in patients whose hypertension is not adequately controlled by monotherapy. Additionally, it has been evaluated in Phase 4 clinical trials (such as the REVERT-K study) for concomitant use with lipid-lowering therapies in patients presenting with both hypertension and hyperlipidemia.
- Brand names
- Mahviren
- Other names
- Candesartan/AmlodipineCandesartan cilexetil/amlodipine besylate
02
Targets
LTCC (Voltage-gated calcium channel (L-type))AGTR1 (Angiotensin II Type-1 receptor)
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