Drug intelligence / Profile preview

cannabidiol (lipid formulation, King's College London)

Development stage
Unknown
Lead developer
King's College London
Modality
Small Molecules
Administration
Oral
01

Overview

A novel lipid-based oral formulation of cannabidiol (CBD) developed by King's College London to address the poor oral bioavailability and significant food effect associated with standard CBD formulations. CBD is a non-intoxicating cannabinoid that interacts with the endocannabinoid system and various neurotransmitter receptors. This specific formulation uses EU pharmacopoeia-approved lipid excipients to enhance absorption in the fasted state, achieving approximately nine times higher plasma exposure than standard powder formulations in Phase 1 trials. It is being investigated for central nervous system disorders, including psychotic disorders, epilepsy, anxiety, and substance use disorders.

Other names
Novel lipid formulation of cannabidiolLipid-based cannabidiol
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)GPR55 (G protein-coupled receptor 55)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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