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cannabidiol + morphine sulfate
- Development stage
- Unknown
- Lead developer
- Wayne State University
- Modality
- Small Molecules
- Administration
- Oral, Inhalation
01
Overview
cannabidiol + morphine sulfate is an investigational drug combination being evaluated by Wayne State University for its potential opioid-sparing effects in the management of chronic pain. The combination consists of smoked cannabidiol (CBD), a non-psychoactive cannabinoid derived from the *Cannabis sativa* plant, and oral morphine sulfate, a potent opioid analgesic. CBD is thought to modulate the endocannabinoid system and interact with various non-cannabinoid receptors, such as 5-HT1A and GPR55, which may influence pain signaling and the rewarding properties of opioids. Morphine acts primarily as an agonist at the mu-opioid receptor to provide analgesia. The Phase 1 human laboratory study (CMP) aims to determine if CBD can enhance morphine's analgesic efficacy or reduce its side effect profile, potentially offering a novel therapeutic strategy to decrease opioid reliance.
- Other names
- CBD and Morphine for Pain SensitivityCBD/Morphine CombinationsCMP
02
Targets
UGT2B7 (UDP-glucuronosyltransferase 2B7)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)GPR55 (G protein-coupled receptor 55)MOR (Mu opioid receptor)
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