Drug intelligence / Profile preview

cannabidiol + tetrahydrocannabinol (One World Cannabis)

Development stage: Unknown
Lead developer: OWC Pharmaceutical Research
Modality: Small Molecules
Administration: Topical

Overview

A topical cream formulation containing a 1:1 ratio of 3% cannabidiol (CBD) and 3% tetrahydrocannabinol (THC), developed by One World Cannabis (OWC) Ltd. for the treatment of psoriasis. This medical-grade cannabis (MGC) product utilizes phytocannabinoids derived from *Cannabis sativa* to target the endocannabinoid system within the skin. The mechanism of action involves the modulation of cannabinoid receptors (CB1 and CB2) and associated signaling pathways to inhibit the excessive keratinocyte proliferation and chronic inflammation that characterize psoriatic lesions. Clinical development has progressed through a Phase I study, which established the safety and tolerability of the cream when applied twice daily in healthy subjects, with subsequent Phase II trials planned to evaluate therapeutic efficacy in patients with psoriasis.

Brand names: MGC cream
Other names: medical grade cannabis creamOWC medical grade cannabis cream

Targets

CNR1 (Cannabinoid receptor 1)CYP2D6 (Cytochrome P450 2D6)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP3A4 (Cytochrome P450 3A4)CYP1A2 (Cytochrome P450 1A2)CYP2B6 (Cytochrome P450 2B6)

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