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A combination of three natural cannabinoids derived from Cannabis sativa: **cannabidiol (CBD)**, **tetrahydrocannabinol (THC)**, and **cannabidivarin (CBDV)**. Each component acts on the endocannabinoid system with both overlapping and distinct mechanisms. - **THC** is a partial agonist at cannabinoid CB1 and CB2 receptors, producing psychoactive and analgesic effects. - **CBD** is a negative allosteric modulator at the CB1 receptor and modulates several other targets, contributing to anticonvulsant, anxiolytic, and anti-inflammatory effects. - **CBDV**, a non-psychoactive homolog of CBD, may modulate neuronal excitability and has shown potential anticonvulsant effects. Recent laboratory studies indicate that **CBDV may counteract or reverse some THC+CBD effects on neuronal firing, suggesting unique neuroregulatory properties**[1][2][4]. This combination has not been approved as a standardized commercial medicinal product but mirrors "full spectrum" cannabinoid extracts under investigation for various neurological and pain indications[2][3].
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