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capecitabine + irinotecan + bevacizumab
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Capecitabine + irinotecan + bevacizumab is a combination chemotherapy regimen used primarily for the treatment of metastatic colorectal cancer. Capecitabine is an oral prodrug of 5-fluorouracil, which inhibits DNA synthesis in rapidly dividing cells. Irinotecan is a topoisomerase I inhibitor that prevents DNA replication and transcription in cancer cells. Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor A (VEGF-A), thereby inhibiting angiogenesis and tumor blood supply. This triplet regimen has demonstrated efficacy as first-line therapy for metastatic colorectal cancer, with studies showing improved progression-free survival and overall survival compared to doublet regimens[1][2][6]. The combination may be associated with increased toxicity, requiring dose adjustments in certain patient populations[3][4].
- Brand names
- Xeloda (capecitabine)Camptosar (irinotecan)Avastin (bevacizumab)
- Other names
- capecitabine + irinotecan + bevacizumabCAPIRI-BEVXELIRI-BEVCIRB
02
Targets
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