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Drug intelligence / Profile preview
Capecitabine + oxaliplatin
- Development stage
- Phase 3
- Lead developer
- Roche
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Capecitabine + oxaliplatin is a combination chemotherapy regimen commonly referred to as CAPOX or XELOX. It consists of two drugs: - Capecitabine (an oral prodrug of 5-fluorouracil) and - Oxaliplatin (a platinum-based chemotherapeutic agent). This combination is primarily used for the treatment of colorectal cancer but is also indicated for other gastrointestinal cancers such as gastric and biliary tract cancers. Capecitabine works by being converted in the body to 5-fluorouracil, which inhibits DNA synthesis in rapidly dividing cells. Oxaliplatin causes DNA crosslinking and damage through its platinum moiety, leading to apoptosis in cancer cells. Together, these agents target rapidly dividing tumor cells via complementary mechanisms that disrupt DNA replication and repair[1][2][3][5][6].
- Brand names
- XELOXCAPOX
- Other names
- CapeOxcapecitabine + oxaliplatin
02
Targets
DNATS (Thymidylate synthase)
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