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capecitabine + peginterferon alfa-2a
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Subcutaneous
01
Overview
**Capecitabine + peginterferon alfa-2a** is a combination drug regimen consisting of capecitabine, an oral fluoropyrimidine carbamate prodrug of 5-fluorouracil (5-FU), and peginterferon alfa-2a, a pegylated recombinant alpha interferon. Capecitabine is selectively activated within tumors to 5-FU, which inhibits thymidylate synthase and incorporates into RNA, leading to cytotoxicity in rapidly dividing cells. Peginterferon alfa-2a acts via the interferon alpha/beta receptor, activating the JAK/STAT pathway and stimulating innate immune responses with antiproliferative and immunomodulatory effects. The combination has been investigated primarily in advanced solid tumors, including metastatic renal cell carcinoma, hepatocellular carcinoma, and brain metastases from breast cancer, with trials showing moderate but manageable toxicity and evidence of efficacy in subsets of patients[1][3][4].
- Brand names
- PegasysXeloda
- Other names
- capecitabine and pegylated interferon alfa-2acapecitabine + PEG-interferon alfa-2acapecitabine + peginterferon α-2a
02
Targets
IFNAR2 (Interferon alpha/beta receptor subunit 2)TS (Thymidylate synthase)IFNAR1 (Interferon alpha/beta receptor 1)
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