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capmatinib + erlotinib
- Development stage
- Phase 1
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Combination therapy of capmatinib (a selective MET inhibitor) and erlotinib (an EGFR tyrosine kinase inhibitor) for the treatment of non-small cell lung cancer (NSCLC). This combination specifically targets MET dysregulation, which is both an oncogenic driver in NSCLC and a mechanism of resistance to EGFR-TKIs in patients with EGFR-mutated disease.
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)MET (Mesenchymal-epithelial transition factor receptor)
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