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captopril + hydrochlorothiazide
- Development stage
- Phase 1
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Captopril + hydrochlorothiazide** is an oral fixed-dose antihypertensive combination containing captopril, a competitive angiotensin-converting enzyme inhibitor, and hydrochlorothiazide, a thiazide diuretic. Captopril reduces formation of angiotensin II and aldosterone-mediated vasoconstriction and sodium retention, while hydrochlorothiazide promotes renal sodium and water excretion through inhibition of the distal-tubule sodium-chloride cotransporter. The complementary mechanisms produce additive blood-pressure lowering and the combination is approved for treatment of hypertension. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f0266d1a-2af2-415b-9433-69b5a690f9bb))
- Brand names
- ACE-Hemmer-ratiopharm comp.Capozide
- Other names
- captopril and hydrochlorothiazidecaptopril/hydrochlorothiazidehydrochlorothiazide + captoprilhydrochlorothiazide/captopril
02
Targets
SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)ACE C-domain (Angiotensin-converting enzyme C-domain)
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