carbamide + hydrocortisone

Carbamide + hydrocortisone is a topical combination drug used primarily for the treatment of inflammatory skin conditions such as eczema, atopic dermatitis, psoriasis, and other dermatoses characterized by inflammation and hyperkeratosis. Hydrocortisone is a corticosteroid that reduces inflammation by suppressing the immune response and decreasing the release of inflammatory mediators. Carbamide (urea) acts as a keratolytic agent that softens and moisturizes the skin by increasing water uptake in the stratum corneum. The combination leverages both anti-inflammatory effects (from hydrocortisone) and hydration/keratolytic effects (from carbamide), making it suitable for chronic or hyperkeratotic skin disorders where both inflammation control and barrier repair are needed[9][10][7]. Clinical studies suggest this combination can be effective with fewer side effects compared to more potent corticosteroids[7][9].

Brand names

Carmol HCKeratol HCUremol HC

Other names

hydrocortisone and urea topicalurea and hydrocortisoneCalmuril-hydrocortisonecarbamide-hydrocortisone DAK