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Carboplatin, Topotecan, and Vinorelbine Combination Therapy
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
The combination of carboplatin, topotecan, and vinorelbine is a chemotherapy regimen that has been studied in clinical trials for various types of cancer. This combination brings together three different anticancer agents, each with its own mechanism of action and toxicity profile. Carboplatin is a platinum-based chemotherapy agent that works by forming DNA crosslinks, thereby inhibiting DNA synthesis and function. Topotecan is a topoisomerase I inhibitor derived from camptothecin that prevents DNA unwinding during replication. Vinorelbine is a vinca alkaloid that disrupts microtubule assembly, preventing cell division.
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNA
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