Drug intelligence / Profile preview

carboplatin + cisplatin + nab-paclitaxel + pembrolizumab + pemetrexed

Development stage
Phase 3
Lead developer
Merck
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

This is a combination therapy consisting of multiple anticancer agents used in the treatment of non-small cell lung cancer (NSCLC). The combination includes: - Platinum-based chemotherapy agents (carboplatin and cisplatin) - Nab-paclitaxel (albumin-bound paclitaxel) - Pembrolizumab (an immune checkpoint inhibitor) - Pemetrexed (an antifolate antimetabolite) Different components of this combination have been studied in various clinical trials, though not necessarily all five agents together. Carboplatin or cisplatin are typically used as alternative platinum agents rather than together. These combinations have shown efficacy in treating advanced NSCLC with manageable toxicity profiles.

02

Targets

DNADHFR (Dihydrofolate reductase)GART (GAR transformylase)MicrotubulePDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))

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