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carboplatin + cyclophosphamide + dendritic cell vaccine + doxorubicin + paclitaxel
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Small Molecules
- Administration
- Intradermal, Intravenous, Oral, Subcutaneous
01
Overview
This is a combination therapy regimen that includes multiple chemotherapeutic agents (carboplatin, cyclophosphamide, doxorubicin, paclitaxel) along with dendritic cell (DC) vaccine immunotherapy. The combination aims to achieve synergistic effects by reducing tumor burden through chemotherapy while simultaneously enhancing anti-tumor immune responses via dendritic cell vaccination. Cyclophosphamide specifically helps overcome immunosuppression by reducing regulatory T cells (Tregs), potentially improving the efficacy of the dendritic cell vaccine component.
02
Targets
MicrotubuleTOP2A (DNA topoisomerase II)DNA
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