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carboplatin + nab-paclitaxel + trastuzumab
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of carboplatin (a platinum-based alkylating agent), nab-paclitaxel (albumin-bound paclitaxel, a taxane), and trastuzumab (a HER2-targeted monoclonal antibody). This regimen is primarily used for HER2-positive breast cancer in both metastatic and neoadjuvant settings. It represents an anthracycline-sparing approach with potentially reduced cardiotoxicity compared to anthracycline-containing regimens.
- Brand names
- Abraxane
- Other names
- nab-paclitaxel + carboplatin + trastuzumabalbumin-bound paclitaxel + carboplatin + trastuzumabnanoparticle albumin-bound paclitaxel + carboplatin + trastuzumab
02
Targets
TUBB (Tubulin (alpha and beta subunits))ERBB2 (Erb-b2 receptor tyrosine kinase 2)DNA
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