Drug intelligence / Profile preview

carboplatin + paclitaxel + panitumumab

Development stage
Unknown
Lead developer
Amgen
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

A combination therapy consisting of two chemotherapy drugs (carboplatin and paclitaxel) and a targeted monoclonal antibody (panitumumab). Carboplatin is a platinum-based chemotherapy that forms DNA crosslinks, preventing DNA repair. Paclitaxel is a taxane that stabilizes microtubules, preventing cell division. Panitumumab is a fully human IgG2 monoclonal antibody that targets the epidermal growth factor receptor (EGFR), blocking ligand binding and inhibiting tumor growth.

Other names
panitumumab + carboplatin + paclitaxel
02

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