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carboxymethyl cellulose + curcumin
- Development stage
- Preclinical
- Lead developer
- Kaken Pharmaceutical
- Modality
- Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Carboxymethyl cellulose + curcumin is a **combination of an anionic cellulose derivative (carboxymethyl cellulose, CMC)** and **curcumin**, the principal bioactive compound from turmeric. This combination is investigated primarily as a **biomaterial for drug delivery and wound dressing applications**. CMC acts as a biocompatible and biodegradable polymer matrix with high swelling and water retention properties, while curcumin provides potent **antioxidant, anti-inflammatory, and antimicrobial activities**[1][2][3][4]. Studies show this combination enhances wound healing by promoting cellular viability, reducing oxidative stress, and inhibiting the growth of pathogenic microorganisms. Curcumin's main mechanisms include scavenging reactive oxygen species and inhibiting inflammatory pathways, while CMC enables controlled release and protection of curcumin from degradation. The combination may be formulated as films, hydrogels, or nanogels for topical (transdermal) application, notably for skin cancer, wound healing, or antimicrobial purposes.
- Other names
- carboxymethyl cellulose + curcumin
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