Drug intelligence / Profile preview

carboxymethyl cellulose + fluorometholone

Development stage
Unknown
Lead developer
DifGen Pharmaceuticals
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Ophthalmic
01

Overview

This is a fixed-dose ophthalmic combination of carboxymethyl cellulose and fluorometholone, used primarily for the treatment of dry eye syndrome and ocular surface inflammation. Carboxymethyl cellulose acts as an artificial tear and lubricant, binding to corneal epithelial cells to facilitate wound healing, reduce irritation, and protect the ocular surface. Fluorometholone is a synthetic glucocorticoid corticosteroid with anti-inflammatory properties that suppresses inflammatory responses in the eye by inhibiting multiple inflammatory cytokines and mediators. The combination provides both symptomatic relief (lubrication) and addresses underlying inflammation associated with moderate to severe dry eye disease[1][2][3][7].

02

Targets

GR (Glucocorticoid receptor)GLUT1 (Glucose transporter 1)

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