carmustine (Massachusetts Institute of Technology)

**Carmustine intracranial wafer** is a biodegradable local chemotherapy implant marketed as **Gliadel Wafer**. Each wafer contains 7.7 mg of the nitrosourea alkylating agent carmustine in a polifeprosan 20 biodegradable copolymer matrix. Implanted into the tumor-resection cavity during neurosurgery, the matrix hydrolyzes and provides sustained local release of carmustine into adjacent brain tissue. Carmustine covalently alkylates DNA and RNA, producing cytotoxic lesions and DNA cross-links that inhibit nucleic-acid replication and trigger tumor-cell death. The product is approved for newly diagnosed high-grade glioma as an adjunct to surgery and radiation and for recurrent glioblastoma as an adjunct to surgery. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=38962a55-a514-4c48-bea5-f99a8da4beec))

Brand names

GliadelGliadel Waferギリアデル

Other names

carmustine implantcarmustine intracranial implant wafercarmustine intracranial wafercarmustine waferpolifeprosan 20 with carmustine implantpolifeprosan20 with carmustine implantpolifeprosan-20 with carmustine implant