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carmustine + cyclophosphamide + cytarabine + doxorubicin + etoposide + granulocyte-colony stimulating factor + melphalan + prednisone + vincristine-University of Aarhus-peripheral T-cell lymphoma
- Development stage
- Unknown
- Lead developer
- Aarhus University
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This multi-agent chemotherapy regimen was evaluated in the NLG-T-01 clinical trial conducted by the Nordic Lymphoma Group, which included the University of Aarhus. The protocol consists of a dose-intensive induction phase using the CHOEP regimen (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone) followed by a high-dose consolidation phase using the BEAM regimen (carmustine, etoposide, cytarabine, and melphalan). The treatment is supported by autologous stem cell transplantation (ASCT) and granulocyte-colony stimulating factor (G-CSF) to manage hematological toxicity. This sequential approach was designed for treatment-naive patients with peripheral T-cell lymphoma (PTCL), excluding ALK-positive anaplastic large cell lymphoma, and has demonstrated significant efficacy in improving progression-free and overall survival in this patient population.
- Other names
- CHOEP followed by BEAMCHOEP + BEAMNordic PTCL regimendose-intensive CHOEP induction and high-dose BEAM consolidation
02
Targets
TOP2A (DNA topoisomerase II)CSF3R (Granulocyte colony-stimulating factor receptor)DNA polymerase familyGR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))
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