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cashew + shrimp
- Development stage
- Unknown
- Lead developer
- Stanford University
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
"Cashew + shrimp" refers to the food allergen oral immunotherapy (OIT) investigated in the MOTIF (Monitoring T cells in Food Allergy) Phase 2 clinical trial (NCT03504774). This investigational approach involves the oral administration of specific food proteins—either cashew or shrimp—to induce immune desensitization in individuals with proven allergies. The therapy aims to modulate allergen-specific immune responses, specifically targeting CD4+ T cells (CD154+/CD28) and IgE-mediated pathways to increase the threshold of reaction and potentially achieve sustained unresponsiveness. The research is led by Dr. Sayantani B. Sindher at the Sean N. Parker Center for Allergy and Asthma Research at Stanford University.
- Other names
- cashew oral immunotherapyshrimp oral immunotherapycashew proteinshrimp protein
02
Targets
T-cell receptor specific for cashew or shrimp allergen peptidesBCR (Immunoglobulin G B Cell Receptor)
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