CBD + THC + Piperine + PNL

CBD + THC + Piperine + PNL is an advanced drug delivery system that combines cannabinoids (CBD and THC) with piperine in a Pro-NanoLiposphere (PNL) formulation. This innovative formulation was developed to overcome the poor oral bioavailability of cannabinoids, which are highly lipophilic molecules with limited solubility in aqueous environments and susceptible to extensive first-pass metabolism[1][3]. The PNL delivery system consists of medium chain triglycerides, surfactants, and co-solvents that self-emulsify into nanoparticles, entrapping the cannabinoids and piperine in their core. This improves the solubility of the cannabinoids while piperine and other PNL excipients inhibit their intestinal metabolism[1]. Piperine, a natural alkaloid, was specifically selected for this formulation due to its distinctive inhibitory properties affecting both Phase I and Phase II metabolism. Clinical studies have shown that the addition of piperine to the PNL formulation significantly enhances the bioavailability of cannabinoids[1][3]. ## Key Benefits The CBD + THC + Piperine + PNL formulation has demonstrated remarkable improvements in cannabinoid bioavailability: - For THC: A 3-fold increase in Cmax (maximum concentration) and a 1.5-fold increase in AUC (area under the curve) compared to Sativex® oromucosal spray[1] - For CBD: A 4-fold increase in Cmax and a 2.2-fold increase in AUC compared to Sativex®[1] - In another study, THC-Piperine-PNL showed a 9.3-fold increase in AUC compared to THC solution[3] - CBD-Piperine-PNL resulted in a 6-fold increase in AUC compared to CBD solution[3] ## Formulation Characteristics The CBD + THC + Piperine + PNL formulation creates a clear and homogeneous pre-concentrate. When diluted with water (1:10 v/v), it forms a visually clear and stable nano-dispersion with particles of approximately 40 nm in size and exhibits a high drug load of >99%[3]. ## Safety Profile An important advantage of this formulation is that its components are approved for human consumption, making it safe for clinical evaluation. The formulation has been tested in human clinical trials, including a two-way crossover, single administration clinical study with 9 healthy volunteers under fasted conditions[1]. ## Potential Applications This advanced formulation shows promise as a standardized oral cannabinoid delivery system with improved bioavailability. The concept could potentially be applied to other lipophilic compounds that require enhancement of their oral bioavailability[1].

Other names

CBD-THC-Piperine-PNL capsuleOral THC-CBD Piperine-Pro-Nano-LiposphereTHC-CBD-piperine-PNL formulation